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1.The canal should be reasonably dry, with no ‘weeping’ of fluids in the form of bleeding or discharge of serous fluids
2.Optimal shaping and cleaning of the canal can be easily achieved in a tooth with vital pulp tissues.Extra care and attention should be given while cleaning a canal with necrotic and infected pulp.
3.Failure of treatment is more common in teeth with pre-exixting periradicular radiolucency than in teeth with no periradicular changes.Stringent clinical Protocols should be adhered in such cases before deciding the timing of the obturation.
4.When seepage into the root canal is excessive, it can be treated and eliminated by reinstrumentation and enlarging the canal,irrigating and sealing it with an intracanal medicament like calcium hydroxide.

(Source: Grossman)